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Vote for Ability Mail Server
Ability Mail Server is capable of running on both the Internet and a LAN (i.e. for external and/or internal mail systems). Features include incoming / outgoing SMTP, POP3, WebMail, Remote Admin, Virus Protection, mailing lists, static routing, automatic sign-ups, aliases, redirection, auto-responses, mulitple folders, address books and more. This allows you to run a very flexible mail service, giving your users access to their mail through any email client (such as Outlook) and also from any web browser (Hotmail style access). All these features are controlled via the built in setup wizard. For more experienced users, there is also the option of configuring all the settings manually.